Undergraduate Teaching 2017-18

Engineering Tripos Part IIA, 3G2: Mathematical Physiology, 2015-16

Engineering Tripos Part IIA, 3G2: Mathematical Physiology, 2015-16

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Module Leader

Dr A Kabla


Dr A Kabla and Dr M Lengyel

Lab Leader

Dr A Kabla

Timing and Structure

Lent term. 16 lectures.


The aims of the course are to:

  • Focus on the quantitative modelling of biological systems


As specific objectives, by the end of the course students should be able to:

  • Have a basic grasp of what functions are necessary for a living organism.
  • Have an overview of the modelling techniques that are used to understand those functions.


A wide variety of topics are touched upon, from biochemistry and cellular function to neural activity and respiration. In all cases, the emphasis is on finding the simplest mathematical model that describes the observations and allows us to identify the relevant physiological parameters. The models often take the form of a simple functional relationship between two variables, or a set of coupled differential equations. The course tries to show where the equations come from and lead to: what assumptions are needed and what simple and robust conclusions can be drawn.

Physical and chemical principles (4L A Kabla)

  • Molecular transport, diffusion, osmotic pressure
  • Chemical reactions, law of mass action, kinetics
  • Enzyme catalysis, Michaelis-Menten model, cooperativity.
  • Gases, partial pressures and solubility

Electrophysiology (5L M Lengyel)

  • Biophysical bases of cellular electrogenesis and basic ingredients of the equivalent circuit model.
  • Action potential generation in neurons: Hodgkin-Huxley model.
  • Phase plane analysis;reduced models,extension to bursting and pacemaking activity
  • Signal propagation along dendritic and axonal projections, and across chemical and electrical synapses. .

Blood Physiology (3L A Kabla)

  • Blood physiology, composition
  • Gas storage in red blood cells
  • Blood rheology, Cason equation, flow in capilleries

Physiological transport systems (4L A Kabla)

  • Circulatory system, heart, cardiac output, arterial pulse
  • Vessel compliance, pulsatile flow profile
  • flow in caplliery beds, filtration
  • Respiratory system, gas exchange in the lungs, ventilation-perfusion


Physiology of speech production. Vocal tract acoustics & dynamics of the vocal folds.


Please see the Booklist for Part IIA Courses for module references.

Examination Guidelines

Please refer to Form & conduct of the examinations.


The UK Standard for Professional Engineering Competence (UK-SPEC) describes the requirements that have to be met in order to become a Chartered Engineer, and gives examples of ways of doing this.

UK-SPEC is published by the Engineering Council on behalf of the UK engineering profession. The standard has been developed, and is regularly updated, by panels representing professional engineering institutions, employers and engineering educators. Of particular relevance here is the 'Accreditation of Higher Education Programmes' (AHEP) document which sets out the standard for degree accreditation.

The Output Standards Matrices indicate where each of the Output Criteria as specified in the AHEP 3rd edition document is addressed within the Engineering and Manufacturing Engineering Triposes.

Last modified: 30/06/2015 12:30