Dr S Huang, Dr A Markaki, Dr R Daly
Dr A Markaki
Timing and Structure
Michaelmas term. 16 lectures.
The aims of the course are to:
- Develop an understanding of the materials issues associated with man-made and naturally-derived materials for medical purposes. Specific case studies will be considered in addition to the general framework.
As specific objectives, by the end of the course students should be able to:
- Identify the mechanism by which medical devices and implants come to market.
- Know about the classes of materials used in medical materials and the associated reasons.
- Understand the requirements for materials used in the body and assess potential for implant-body interactions.
- Perform quantitative evaluations of drug delivery.
- Identify appropriate implants and tissue engineering approaches for tissue and body function replacements.
- Understand bioethics and safety regulations associated with medical devices and implants.
Course overview with introduction to biomaterials and medical devices (1L)
- Medical devices detailed definitions and classifications
- Classes of biomaterials overview
Bioethics and Material Sterilisation (1L)
- Origins of bioethics and contemporary challenges
- Definitions, techniques and metrology
Sector Analysis and Regulatory Affairs (1L)
- Areas of growth, market values
- Market trends
- Role of standards
- Approval process
Personalised Medicine and Future Technologies (1L)
- Personalised medinine
- Basic introduction to tissue engineering
- Advanced and nanotechnology
Synthetic polymers for tissue engineering applications (2L)
- Introduction to polymers
- Synthetic biodegradable polymers
Host response to implants (1L)
- Wound repair
- Innate immunity
- The biological response to biomaterials
Using cells in tissue engineering (1L)
- What happens when biomaterials fail
- Cell therapy
- Combining cells with scaffolds
- Working with biology - implant integration and vascularisation
Naturally derived polymers for tissue engineering application (1L)
Drug delivery and diffusion (2L) + Q&A (1L)
- Drug delivery systems
- Diffusion controlled systems in drug delivery
Orthopaedic Implants - Hip Replacement (1.5L)
- Types of implant fixation
- Materials in hip implants
- Surface engineering approaches
- In vivo loading of hip joint
Cardiovascular Stents (2.5L)
- Balloon expandable & self expanding stents
- Materials in stents
- Stent mechanics and design
Example papers are available on Moodle.
Full Technical Report:
Students will not have the option to submit a Full Technical Report.
Biomedical Engineering: Bridging Medicine and Technology by W. Mark Saltzman
Biomaterial Science: An Introduction to Materials in Medicine. Edited by Ratner et al.
Please refer to Form & conduct of the examinations.
Last modified: 20/05/2021 07:40