Prof A Seshia and Professor E A Hall
Timing and Structure
Lent term. Lectures and coursework. Assessment: 100% coursework.
The aims of the course are to:
- link engineering principles to understanding of biosystems in sensors and bioelectronics
As specific objectives, by the end of the course students should be able to:
- extend principles of engineering to the development of bioanalytical devices and the design of biosensors.
- understand the principles of linking cell components and biological pathways with energy transduction, sensing and detection
- appreciate the basic configuration and distinction among biosensor systems.
- demonstrate appreciation for the technical limits of performance.
- make design and selection decisions in response to measurement problems amenable to the use of biosensors.
This course covers the principles, technologies, methods and applications of biosensors and bioinstrumentation. The objective of this course is to link engineering principles to understanding of biosystems in sensors and bioelectronics. It will provide the student with detail of methods and procedures used in the design, fabrication and application of biosensors and bioelectronic devices. The fundamentals of measurement science are applied to optical, electrochemical, mass, and pressure signal transduction. Upon successful completion of this course, students are expected to be able to explain biosensing and transduction techniques, as well as design and construct biosensor instrumentation.
- Overview of Biosensors
- Fundamental elements of biosensor devices
- Engineering sensor proteins
- Electrochemical principles
- Amperometric biosensors and charge transfer pathways in enzymes
- Glucose biosensors
- Engineering electrochemical biosensors
- Optics for biosensors
- Attenuated total reflection systems
- Analytical models
- Acoustic sensor formats
- Quartz crystal microbalance
Micro- and Nano-technologies for biosensors
- Microfluidic interfaces for biosensors
- DNA and protein microarrays
- Microfabricated PCR technology
Diagnostics for the real world
- Communication and tracking in health monitoring
- Detection in resource limited settings
The coursework will be assessed on two marked assignments. The first assignment will involve a laboratory session illustrating the functional demonstration of glucose sensor technology. The second assignment will involve a laboratory session illustrating the principle of a quartz crystal microbalance and related acoustic sensor technologies.
Coursework activity #1 Glucose biosensors
Mon week 5
[Coursework activity #2 Quartz crystal microbalance]
Wed week 9
Please see the Booklist for Group G Courses for references for this module.
Please refer to Form & conduct of the examinations.
The UK Standard for Professional Engineering Competence (UK-SPEC) describes the requirements that have to be met in order to become a Chartered Engineer, and gives examples of ways of doing this.
UK-SPEC is published by the Engineering Council on behalf of the UK engineering profession. The standard has been developed, and is regularly updated, by panels representing professional engineering institutions, employers and engineering educators. Of particular relevance here is the 'Accreditation of Higher Education Programmes' (AHEP) document which sets out the standard for degree accreditation.
The Output Standards Matrices indicate where each of the Output Criteria as specified in the AHEP 3rd edition document is addressed within the Engineering and Manufacturing Engineering Triposes.
Last modified: 05/10/2017 11:12