Timing and Structure
Lent term. Lectures and coursework. Assessment: 100% coursework.
The aims of the course are to:
- Link engineering principles to understanding of biosystems in sensors and bioelectronics.
As specific objectives, by the end of the course students should be able to:
- Extend principles of engineering to the development of biosensors and bioelectronic devices.
- Understand the principles of signal transduction between biology and electronics. • appreciate the basic configuration and distinction among biosensors and bioelectronic systems.
- Appreciate the basic configuration and distinction among biosensors and bioelectronic systems.
- Demonstrate appreciation for the technical limits of performance.
- Make design and selection decisions in response to measurement and actuation problems amenable to the use of biosensors and bioelectronic devices.
- Be able to evaluate novel trends in the field.
This course covers the principles, technologies, methods and applications of biosensors and bioelectronics. The objective of this course is to link engineering principles to understanding these biosystems. It will provide the student with detail of methods and procedures used in the design, fabrication and application of biosensors and bioelectronic devices. The fundamentals of measurement science are applied to electrochemical and optical signal transduction. The fundamentals of electrophysiology are applied to implantable and cutaneous bioelectronic devices. Upon successful completion of this course, students are expected to be able to explain biosensing and transduction techniques, design and construct biosensor instrumentation, and explain the techniques of recording and stimulation of electrically active cells and tissues.
Introduction to Biosensors
- Overview of Biosensors
- Fundamental elements of biosensor devices
- Engineering sensor proteins
- Electrochemical principles
- Amperometric biosensors and charge transfer pathways in enzymes
- Glucose biosensors
- Engineering electrochemical biosensors
- Optics for biosensors
- Attenuated total reflection systems
Diagnostics for the real world
- Communication and tracking in health monitoring
- Detection in resource limited settings
Introduction to Bioelectronics
- Overview of technology (implantable, cutaneous, ex vivo)
- Anatomy, function of nervous system, other electrically active tissues
- Principles of electrophysiology
- Recording and stimulation (intracellular, extracellular, epidural, EEG)
- Transducers (pipette electrodes, Ag/AgCl, metal electrodes, Michigan and Utah probes, transistors)
- Cardiac pacemaker
- Cochlear implant, retinal implant
- DBS (Parkinson’s, dystonia, epilepsy), spinal cord stimulators
- Brain-Computer Interfaces
- PNS stimulators, electroceuticals
- Implantable drug delivery systems
- Foreign body reaction
- Cutaneous electrophysiology (brain, heart, muscle)
- Electronic skins (pressure, temperature)
- Sweat biosensing (glucose, lactate, …)
- Transdermal drug delivery
Ex vivo devices
- Electrochemical biosensors
- Impedance biosensors
- MEAs and patch clamp
- In vitro systems
Regulatory and ethical issues
The coursework will be assessed on two marked assignments. The first assignment will involve a laboratory session illustrating the functional demonstration of glucose sensor technology. The second assignment will involve a laboratory session illustrating the principles of electrophysiology applied to bioelectronic devices.
[Coursework activity #1 : Glucose biosensors]
[Coursework activity #2 : Cutaneous electrophysiology]
Please refer to the Booklist for Part IIB Courses for references to this module, this can be found on the associated Moodle course.
Please refer to Form & conduct of the examinations.
The UK Standard for Professional Engineering Competence (UK-SPEC) describes the requirements that have to be met in order to become a Chartered Engineer, and gives examples of ways of doing this.
UK-SPEC is published by the Engineering Council on behalf of the UK engineering profession. The standard has been developed, and is regularly updated, by panels representing professional engineering institutions, employers and engineering educators. Of particular relevance here is the 'Accreditation of Higher Education Programmes' (AHEP) document which sets out the standard for degree accreditation.
The Output Standards Matrices indicate where each of the Output Criteria as specified in the AHEP 3rd edition document is addressed within the Engineering and Manufacturing Engineering Triposes.
Last modified: 07/10/2020 09:20